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KMID : 0861020140290020047
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Korea Journal of Herbology
2014 Volume.29 No. 2 p.47 ~ p.54
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Gangjihwan Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed C57BL/6N Mice
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Ahn Ye-Ji
Yoon Ki-Hyeon
Jo Ju-Heum
Jang Du-Hyon
Jung Yang-Sam
Kim Jong-Hoon
Kim Byoung-Chul
Seok Hoa-Jun
Yoo Jae-Sang
Ku Ja-Ryong
Yoon Mi-Jung
Shin Soon-Shik
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Abstract
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Objectives : This study was undertaken to verify the effect of Gangjihwan(Di-fatty, DF) composed with Pakistani Ephedra Herba on nonalcoholic fatty liver disease(NAFLD) using high fat diet-fed male mice.
Method : Eight-week old C57BL/6N mice were used for all experiments. Standard chow diet-fed mice were used as normal group and high fat diet-fed NAFLD mice were randomly divided into 5 groups: control, atorvastatin, DF(1), DF(2) and DF(3). After 8 weeks, mice were treated with water, atorvastatin(10mg/kg) and DF(40, 80, 160mg/kg) for 8 weeks. And we investigated body weight gain, plasma lipid and glucose metabolism, histological analysis for liver on the mice.
Results : Compared with controls, DF-treated mice had very significantly lower body weight gain and lower visceral adipose tissue weight, the magnitudes of which were prominent in DF(3). Consistent with their effects on body weight gain, DF-treated mice had lower blood total cholesterol and triglyceride level compared with controls. Consistent with their effects on body weight gain and blood plasma lipid level, DF-treated mice had lower liver weight and hepatic lipid accumulation of DF-treated groups was significantly decreased than control group. Also Blood plasma AST, ALT and γ-GT concentration were not changed by DF, and these results may indicate DF do not show any toxic effects.
Conclusions : These results suggest that DF effectively improves NAFLD. DF reduces liver weight and prevents lipid accumulation of hepatocyte by reducing body weight gain and modulating blood plasma lipid metabolism levels.
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KEYWORD
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Gangjihwan, DF, Di-fatty, nonalcoholic fatty liver disease, NAFLD, triglyceride, cholesterol
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